Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat
نویسندگان
چکیده
An 18-month-old male Brown Norway (BN) rat showed a grayish-white subcutaneous mass in the right cheek. Histologically, the mass was composed of highly pleomorphic cells producing collagen. Immunohistochemical analysis showed that the tumor cells were strongly positive for vimentin and partially positive for Ki-67; however, they were negative for ED-1, ED-2, S-100, cytokeratin, desmin and myoglobin. Ultrastructurally, the cytoplasms of the tumor cells contained well-developed rough endoplasmic reticulum. Thus, the tumor had no characteristic feature other than collagen production and was diagnosed as a fibrosarcoma.
منابع مشابه
(CANCER RESEARCH 31, 953—956,July 1971] SUMMARY Histological examination of an invasive neoplasm from an 18-month-old female domestic shorthair cat revealed it to be a pleomorphic fibrosarcoma that ranged in microscopic appearance from well-differentiated collagenous connective tissue to anaplastic sarcomatous
Histological examination of an invasive neoplasm from an 18-month-old female domestic shorthair cat revealed it to be a pleomorphic fibrosarcoma that ranged in microscopic appearance from well-differentiated collagenous connective tissue to anaplastic sarcomatous tissue that infiltrated surrounding musculature and skin. The fibrosarcoma was transmitted by whole cells or cell-free preparations t...
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عنوان ژورنال:
دوره 23 شماره
صفحات -
تاریخ انتشار 2010